San Francisco 49ers 2022 Player Roster | NFL.com
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| Player | No | Pos | Status | Height | Weight | Experience | College |
|---|---|---|---|---|---|---|---|
| 11 | WR | ACT | 72 | 200 | 3 | Arizona State | |
| 51 | LB | ACT | 74 | 228 | 4 | Florida Atlantic | |
| 91 | DE | ACT | 79 | 290 | 8 | Oregon | |
| DE | ACT | 74 | 308 | R | Fresno State | ||
| 65 | G | ACT | 77 | 325 | 2 | Notre Dame | |
| 94 | DE | ACT | 74 | 250 | 2 | San Diego State | |
| 17 | WR | UFA | 70 | 175 | 10 | Miami | |
| 97 | DE | ACT | 76 | 266 | 4 | Ohio State | |
| 64 | C | ACT | 76 | 299 | 4 | UCLA | |
| 60 | OT | ACT | 77 | 300 | 4 | San Diego State | |
| OT | UDF | 77 | 300 | R | Texas-San Antonio | ||
| ILB | ACT | 75 | 233 | 5 | Vanderbilt | ||
| CB | UDF | 72 | 197 | R | Penn State | ||
| DT | UDF | 74 | 310 | R | UCF | ||
| RB | UDF | 73 | 219 | R | LSU | ||
| DB | ACT | 71 | 202 | 8 | Michigan State | ||
| 82 | TE | ACT | 77 | 235 | 5 | San Diego | |
| 56 | OLB | ACT | 75 | 245 | 6 | Eastern Washington | |
| 45 | LB | ACT | 74 | 223 | 3 | Arizona | |
| 55 | OLB | ACT | 74 | 252 | 9 | Auburn | |
| TE | ACT | 78 | 248 | 5 | Wisconsin | ||
| 10 | QB | ACT | 74 | 225 | 9 | Eastern Illinois | |
| LB | ACT | 73 | 225 | R | North Carolina | ||
| 90 | DT | ACT | 73 | 285 | 3 | Penn State | |
| 9 | K | ACT | 72 | 190 | 18 | Penn State | |
| WR | UDF | 74 | 199 | R | SMU | ||
| 57 | LB | ACT | 72 | 230 | 4 | Arkansas | |
| 77 | OT | ACT | 81 | 332 | 1 | ||
| 23 | RB | ACT | 68 | 205 | 3 | Baylor | |
| SAF | ACT | 73 | 205 | R | San Diego State | ||
| 40 | RB | ACT | 73 | 225 | 1 | Fresno State | |
| CB | ACT | 72 | 196 | 3 | Toledo | ||
| 84 | TE | ACT | 77 | 239 | 3 | Southern Arkansas | |
| 29 | SAF | ACT | 72 | 200 | 2 | USC | |
| 96 | DT | ACT | 74 | 291 | 5 | Michigan | |
| DE | ACT | 74 | 275 | 7 | Texas Tech | ||
| DE | UDF | 76 | 273 | R | USC | ||
| 15 | WR | ACT | 75 | 212 | 2 | Tennessee | |
| WR | ACT | 73 | 201 | 3 | Fresno State | ||
| 27 | DB | ACT | 74 | 200 | 9 | N.C. State | |
| WR | ACT | 73 | 207 | 6 | Texas | ||
| 44 | FB | ACT | 73 | 235 | 10 | Harvard | |
| 99 | DT | ACT | 77 | 319 | 3 | South Carolina | |
| 85 | TE | ACT | 76 | 250 | 6 | Iowa | |
| CB | ACT | 72 | 199 | R | UCLA | ||
| TE | ACT | 78 | 252 | 8 | Rutgers | ||
| 5 | QB | ACT | 76 | 226 | 2 | North Dakota State | |
| 38 | CB | ACT | 70 | 200 | 2 | Oregon | |
| WR | ACT | 74 | 215 | 2 | Ohio State | ||
| 50 | C | ACT | 76 | 311 | 14 | California | |
| WR | ACT | 74 | 190 | R | Pittsburgh | ||
| WR | ACT | 75 | 186 | R | Oklahoma State | ||
| RB | ACT | 71 | 223 | R | Georgia Tech | ||
| 18 | WR | ACT | 75 | 236 | 7 | Vanderbilt | |
| WR | ACT | 69 | 190 | 5 | Clemson | ||
| LB | ACT | 72 | 214 | R | Indiana | ||
| 69 | OT | ACT | 80 | 310 | 5 | Notre Dame | |
| 68 | OT | ACT | 78 | 301 | 3 | West Virginia | |
| 25 | RB | ACT | 70 | 200 | 2 | Louisiana | |
| 76 | OT | ACT | 76 | 311 | 2 | Western Michigan | |
| 33 | DB | ACT | 74 | 200 | 5 | Southern Mississippi | |
| 4 | DB | ACT | 71 | 190 | 5 | Tennessee | |
| 26 | CB | UFA | 72 | 200 | 11 | Coastal Carolina | |
| DB | ACT | 73 | 202 | 5 | Central Arkansas | ||
| LB | ACT | 74 | 220 | R | San Diego State | ||
| 92 | DE | ACT | 77 | 280 | 4 | Texas | |
| DB | ACT | 73 | 210 | R | Texas A&M | ||
| 46 | LS | ACT | 76 | 245 | 5 | Michigan State | |
| C | ACT | 73 | 300 | R | Mercer University, Atlanta | ||
| QB | UDF | 73 | 220 | R | Iowa State | ||
| DT | ACT | 75 | 305 | 7 | Texas | ||
| 59 | LB | ACT | 75 | 235 | 2 | Stanford | |
| 19 | WR | ACT | 72 | 215 | 4 | South Carolina | |
| 6 | WR | UFA | 74 | 210 | 11 | Rutgers | |
| OT | ACT | 78 | 309 | R | Minnesota | ||
| 28 | RB | ACT | 72 | 215 | 2 | Ohio State | |
| 67 | OT | ACT | 78 | 315 | 4 | Vanderbilt | |
| QB | ACT | 78 | 227 | 6 | Indiana | ||
| G | ACT | 77 | 316 | 3 | Texas A&M | ||
| 3 | S | UFA | 73 | 215 | 8 | Samford | |
| 20 | CB | ACT | 72 | 190 | 2 | Michigan | |
| DE | ACT | 77 | 252 | 5 | Rutgers | ||
| WR | ACT | 74 | 202 | 5 | Illinois | ||
| 2 | DB | ACT | 70 | 188 | 9 | TCU | |
| TE | UFA | 76 | 245 | R | North Carolina | ||
| CB | ACT | 73 | 196 | 5 | Middle Tennessee State | ||
| 1 | CB | ACT | 71 | 195 | 9 | Northern Illinois | |
| 54 | MLB | ACT | 75 | 230 | 5 | BYU | |
| G | ACT | 76 | 300 | R | Arizona State | ||
| 71 | OT | ACT | 77 | 320 | 12 | Oklahoma | |
| 78 | DE | ACT | 76 | 270 | 6 | Kansas State | |
| 30 | RB | ACT | 72 | 213 | 5 | North Texas | |
| 32 | DB | UFA | 72 | 208 | 11 | Illinois | |
| 18 | P | ACT | 74 | 220 | 4 | Utah | |
| 89 | TE | ACT | 77 | 241 | 3 | Georgia | |
| CB | UDF | 70 | 187 | R | Toledo | ||
| OT | UDF | 77 | 316 | R | Fordham |
