San Francisco 49ers 2022 Player Roster | NFL.com
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| Player | No | Pos | Status | Height | Weight | Experience | College |
|---|---|---|---|---|---|---|---|
| 11 | WR | ACT | 72 | 200 | 3 | Arizona State | |
| 51 | OLB | ACT | 74 | 228 | 4 | Florida Atlantic | |
| 91 | DT | ACT | 79 | 290 | 8 | Oregon | |
| 65 | G | ACT | 77 | 325 | 2 | Notre Dame | |
| 58 | DE | ACT | 74 | 250 | 2 | San Diego State | |
| 6 | QB | CUT | 75 | 218 | 2 | Virginia | |
| 97 | DE | ACT | 76 | 266 | 4 | Ohio State | |
| 64 | C | ACT | 76 | 299 | 6 | UCLA | |
| 60 | OT | ACT | 77 | 300 | 4 | San Diego State | |
| 74 | G | ACT | 76 | 300 | R | Texas-San Antonio | |
| 48 | OLB | ACT | 75 | 233 | 5 | Vanderbilt | |
| 28 | RB | DEV | 73 | 210 | 8 | Indiana | |
| 93 | DT | RSN | 74 | 310 | R | UCF | |
| 32 | RB | ACT | 73 | 219 | R | LSU | |
| 82 | TE | ACT | 77 | 235 | 5 | San Diego | |
| 50 | DT | DEV | 73 | 296 | 1 | Rutgers | |
| QB | CUT | 78 | 231 | 3 | Washington | ||
| 56 | DE | ACT | 75 | 245 | 6 | Eastern Washington | |
| 45 | LB | ACT | 74 | 223 | 3 | Arizona | |
| 49 | TE | CUT | 78 | 248 | 5 | Wisconsin | |
| 10 | QB | ACT | 74 | 225 | 9 | Eastern Illinois | |
| 31 | FS | ACT | 73 | 207 | 11 | Wyoming | |
| 90 | DT | ACT | 73 | 285 | 3 | Penn State | |
| 9 | K | ACT | 72 | 190 | 18 | Penn State | |
| 86 | WR | ACT | 72 | 200 | R | SMU | |
| 57 | OLB | ACT | 72 | 230 | 4 | Arkansas | |
| 77 | OT | DEV | 81 | 332 | 1 | ||
| 61 | G | TRC | 78 | 310 | 2 | Northwestern | |
| 41 | SAF | DEV | 73 | 205 | R | San Diego State | |
| CB | TRC | 72 | 196 | 3 | Toledo | ||
| 29 | S | ACT | 72 | 200 | 2 | USC | |
| 96 | DT | RES | 74 | 291 | 5 | Michigan | |
| 92 | DE | ACT | 74 | 275 | 7 | Texas Tech | |
| 60 | C | DEV | 75 | 309 | 3 | San Diego State | |
| 95 | DE | ACT | 76 | 273 | R | USC | |
| 20 | CB | ACT | 70 | 190 | 11 | North Alabama | |
| 15 | WR | ACT | 75 | 212 | 2 | Tennessee | |
| 11 | QB | ACT | 74 | 205 | 8 | San Diego | |
| LB | TRC | 74 | 240 | 2 | Texas A&M | ||
| 27 | DB | DEV | 74 | 200 | 9 | N.C. State | |
| 44 | FB | ACT | 74 | 235 | 10 | Harvard | |
| 99 | DT | ACT | 77 | 319 | 3 | South Carolina | |
| 85 | TE | ACT | 76 | 250 | 6 | Iowa | |
| 43 | CB | DEV | 72 | 199 | R | UCLA | |
| 47 | TE | ACT | 78 | 252 | 8 | Rutgers | |
| 5 | QB | RES | 76 | 224 | 2 | North Dakota State | |
| 38 | CB | ACT | 70 | 200 | 2 | Oregon | |
| 23 | RB | TRC | 71 | 210 | 6 | University of South Florida | |
| 83 | WR | DEV | 75 | 186 | R | Oklahoma State | |
| 41 | RB | ACT | 71 | 223 | R | Georgia Tech | |
| 88 | TE | RES | 75 | 236 | 7 | Vanderbilt | |
| 23 | RB | ACT | 71 | 205 | 6 | Stanford | |
| 3 | WR | ACT | 69 | 190 | 5 | Clemson | |
| 40 | LB | DEV | 72 | 214 | R | Indiana | |
| 76 | DT | ACT | 72 | 294 | 7 | N.C. State | |
| 69 | OT | ACT | 80 | 310 | 5 | Notre Dame | |
| 68 | OT | ACT | 78 | 301 | 3 | West Virginia | |
| 25 | RB | ACT | 70 | 200 | 2 | Louisiana | |
| 76 | OT | ACT | 76 | 311 | 2 | Western Michigan | |
| 33 | DB | ACT | 74 | 200 | 5 | Southern Mississippi | |
| 4 | CB | RES | 71 | 190 | 5 | Tennessee | |
| 83 | WR | DEV | 70 | 184 | 1 | North Carolina | |
| 30 | DB | ACT | 73 | 202 | 5 | Central Arkansas | |
| 94 | DE | ACT | 77 | 280 | 4 | Texas | |
| 46 | LS | ACT | 76 | 245 | 5 | Michigan State | |
| 62 | C | DEV | 73 | 300 | R | Mercer University, Atlanta | |
| 13 | QB | ACT | 73 | 220 | R | Iowa State | |
| 98 | DT | RES | 75 | 305 | 7 | Texas | |
| 59 | LB | DEV | 75 | 235 | 2 | Stanford | |
| 19 | WR | ACT | 72 | 215 | 4 | South Carolina | |
| 88 | WR | CUT | 76 | 194 | 7 | UMass Amherst | |
| K | CUT | 68 | 205 | 2 | Miami (Ohio) | ||
| 83 | WR | DEV | 71 | 195 | 8 | Ball State | |
| 55 | DT | DEV | 73 | 307 | 9 | Illinois | |
| 66 | G | TRD | 77 | 316 | 3 | Texas A&M | |
| CB | CUT | 72 | 196 | R | Georgia Tech | ||
| 20 | CB | ACT | 72 | 190 | 2 | Michigan | |
| 53 | DE | DEV | 77 | 248 | 5 | Rutgers | |
| 17 | WR | TRC | 74 | 202 | 5 | Illinois | |
| 2 | DB | RES | 70 | 188 | 9 | TCU | |
| CB | CUT | 70 | 189 | 2 | LSU | ||
| 35 | CB | ACT | 73 | 196 | 5 | Middle Tennessee State | |
| 1 | CB | ACT | 71 | 195 | 9 | Northern Illinois | |
| 54 | MLB | ACT | 75 | 230 | 5 | BYU | |
| 72 | TE | DEV | 77 | 275 | R | Texas-San Antonio | |
| WR | TRT | 72 | 204 | 1 | Stanford | ||
| 71 | OT | ACT | 77 | 320 | 13 | Oklahoma | |
| 75 | DE | ACT | 76 | 270 | 6 | Kansas State | |
| 22 | RB | TRC | 72 | 213 | 5 | North Texas | |
| 18 | P | ACT | 74 | 220 | 4 | Utah | |
| 89 | TE | ACT | 77 | 241 | 3 | Georgia | |
| 26 | CB | ACT | 70 | 189 | R | Toledo | |
| 63 | OT | ACT | 78 | 316 | R | Fordham |
