Buffalo Bills 2022 Player Roster | NFL.com
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| Player | No | Pos | Status | Height | Weight | Experience | College |
|---|---|---|---|---|---|---|---|
| 17 | QB | ACT | 77 | 237 | 5 | Wyoming | |
| 70 | OT | DEV | 77 | 305 | R | UCLA | |
| 51 | DT | ACT | 75 | 325 | 6 | UCLA | |
| 86 | WR | CUT | 68 | 185 | 10 | West Virginia | |
| 11 | QB | DEV | 74 | 234 | 10 | USC | |
| 55 | DE | ACT | 75 | 281 | 2 | Wake Forest | |
| 2 | K | ACT | 70 | 183 | 3 | Georgia Southern | |
| 71 | G | ACT | 76 | 302 | 4 | Penn State | |
| 11 | WR | ACT | 68 | 174 | 11 | SMU | |
| 47 | CB | ACT | 73 | 205 | R | Villanova | |
| 43 | OLB | ACT | 73 | 224 | R | Baylor | |
| 35 | RB | TRC | 69 | 190 | R | Virginia Tech | |
| 65 | G | ACT | 78 | 313 | 5 | Iowa | |
| 98 | DT | CUT | 74 | 290 | R | Coastal Carolina | |
| DT | DEV | 74 | 293 | 3 | Cincinnati | ||
| 89 | WR | DEV | 70 | 178 | 8 | Pittsburg State (KS) | |
| 79 | OT | ACT | 80 | 311 | 2 | Northern Iowa | |
| DT | DEV | 74 | 305 | 1 | Florida Atlantic | ||
| 28 | RB | ACT | 71 | 190 | R | Georgia | |
| WR | CUT | 74 | 198 | 2 | Rhode Island | ||
| 80 | WR | RSR | 69 | 177 | 8 | Duke | |
| 84 | TE | DEV | 79 | 251 | 1 | Central Missouri | |
| 13 | WR | ACT | 74 | 210 | 3 | UCF | |
| 73 | OT | ACT | 77 | 320 | 6 | Temple | |
| 14 | WR | ACT | 72 | 191 | 8 | Maryland | |
| 53 | MLB | ACT | 72 | 237 | 3 | Texas A&M | |
| 72 | OT | RES | 80 | 320 | 2 | Miami (Ohio) | |
| 49 | MLB | ACT | 77 | 250 | 5 | Virginia Tech | |
| 24 | CB | ACT | 73 | 191 | R | Florida | |
| 94 | DT | TRC | 74 | 300 | R | Penn | |
| 57 | DE | ACT | 78 | 260 | 3 | Iowa | |
| 69 | LS | ACT | 74 | 235 | 6 | LSU | |
| 87 | WR | CUT | 74 | 209 | 1 | Wyoming | |
| 42 | LB | CUT | 74 | 240 | 2 | Duke | |
| 41 | FB | ACT | 72 | 244 | 3 | Toledo | |
| 3 | S | RES | 72 | 200 | 2 | Pittsburgh | |
| 68 | OT | ACT | 77 | 310 | 8 | Florida State | |
| 20 | RB | ACT | 69 | 198 | 5 | N.C. State | |
| 16 | WR | TRC | 75 | 201 | 2 | Oregon State | |
| 23 | S | RSR | 72 | 197 | 10 | Iowa | |
| 46 | DB | DEV | 74 | 190 | R | Buffalo | |
| 30 | CB | ACT | 71 | 180 | 3 | Pittsburgh | |
| 22 | RB | DEV | 69 | 210 | 8 | Miami | |
| 4 | FS | ACT | 70 | 191 | 4 | Miami | |
| 81 | WR | DEV | 73 | 201 | 3 | Fresno State | |
| 7 | CB | ACT | 71 | 192 | 5 | Weber State | |
| 59 | DE | ACT | 76 | 260 | R | Syracuse | |
| 92 | DE | ACT | 76 | 320 | 9 | Penn State | |
| 25 | RB | ACT | 72 | 195 | 12 | Eastern Washington | |
| 18 | QB | ACT | 73 | 215 | 10 | Houston | |
| 52 | OLB | ACT | 73 | 240 | 10 | Iowa State | |
| 88 | TE | ACT | 76 | 254 | 4 | Mississippi | |
| 15 | WR | RES | 76 | 209 | 5 | Wisconsin-Whitewater | |
| 90 | DE | ACT | 75 | 265 | 7 | Clemson | |
| 39 | CB | ACT | 69 | 183 | 3 | Buffalo | |
| 56 | DE | DEV | 75 | 255 | 2 | University of South Florida | |
| 62 | C | DEV | 76 | 302 | 7 | Toledo | |
| 31 | S | ACT | 73 | 205 | 6 | James Madison | |
| 8 | P | ACT | 73 | 205 | 10 | Appalachian State | |
| 44 | ILB | ACT | 73 | 235 | 7 | Temple | |
| 36 | SAF | ACT | 72 | 205 | 1 | Alabama | |
| 6 | WR | ACT | 68 | 173 | 6 | Georgia | |
| 31 | DB | DEV | 72 | 210 | R | North Carolina | |
| 58 | OLB | ACT | 72 | 223 | 6 | Boston College | |
| 32 | DB | TRC | 74 | 190 | 3 | Washington | |
| 40 | OLB | RES | 75 | 250 | 12 | Texas A&M | |
| 85 | TE | ACT | 74 | 252 | 1 | Bowling Green | |
| 60 | C | ACT | 78 | 305 | 8 | Missouri | |
| 20 | RB | TRD | 69 | 205 | 3 | Utah | |
| OT | DEV | 77 | 315 | 5 | Cincinnati | ||
| 33 | DB | ACT | 72 | 206 | 5 | Jacksonville State | |
| 91 | NT | ACT | 73 | 287 | 4 | Houston | |
| WR | DEV | 76 | 225 | 3 | Washington State | ||
| 97 | NT | ACT | 78 | 330 | 8 | Oklahoma | |
| 21 | FS | ACT | 72 | 191 | 10 | Oregon State | |
| 77 | OT | ACT | 77 | 310 | 5 | San Jose State | |
| 27 | CB | TRC | 73 | 210 | 10 | Florida State | |
| WR | TRC | 73 | 182 | R | Wake Forest | ||
| 50 | DE | ACT | 78 | 266 | 2 | Miami | |
| 76 | G | ACT | 77 | 325 | 13 | Indiana | |
| 99 | NT | ACT | 75 | 313 | 5 | Virginia Tech | |
| 10 | WR | ACT | 72 | 190 | R | Boise State | |
| 26 | RB | ACT | 67 | 203 | 4 | Florida Atlantic | |
| 9 | LB | TRD | 72 | 240 | 5 | North Carolina | |
| 54 | LB | ACT | 72 | 233 | R | Clemson | |
| 5 | WR | TRD | 70 | 180 | 2 | Houston | |
| 89 | TE | ACT | 77 | 251 | 4 | Boston College | |
| 74 | OT | DEV | 77 | 304 | R | Connecticut | |
| 75 | C | ACT | 76 | 295 | 8 | Penn | |
| DE | CUT | 75 | 295 | 3 | Tennessee | ||
| 27 | CB | ACT | 71 | 192 | 6 | LSU | |
| 61 | DT | TRT | 75 | 292 | 4 | Ferris State |
