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NFL Week 6 bold predictions: Cardinals suffer first loss, Lions bank first win

Throughout the 2021 NFL season, NFL Network analysts will provide one bold prediction heading into each week's slate of games (see the full Week 6 schedule).

Joe Thomas: Though some might not expect it, it's a low-scoring affair between the Browns and Cardinals on Sunday. Baker Mayfield has modest numbers, but authors that signature come-from-behind moment. Trailing late in the fourth quarter, Mayfield leads the Browns down the field for the winning score as time expires.

James Jones: The Detroit Lions have been thisclose to winning two games this season. They would already be in the win column if not for a pair of last-second field goals: a record-setting boot from Baltimore's Justin Tucker in Week 3 and a 54-yarder from Minnesota's Greg Joseph in Week 5. Detroit won't have to wait any longer for its first victory of the season, as the Lions take down the 3-2 Bengals in Ford Field.

DeAngelo Hall: Until now, the Buffalo Bills' defense has suffocated opposing rushers. The unit has not allowed 50 or more ground yards to a running back this season -- the most it allowed was 61 to QB Patrick Mahomes last week. But against the best running back in the league, Derrick Henry, the Bills become vulnerable. The two-time reigning rushing champion has run for at least 130 yards and one TD in consecutive games; over the last 10 years, per NFL Research, only Henry (2019) and Adrian Peterson (2012) have reached those figures in three straight outings. The Titans superstar does it again in style, rumbling for 150-plus yards and two scores on Buffalo.

Maurice Jones-Drew: You want bold?! I'll give you BOLD. Chase Claypool found his game last week against the Broncos with five receptions for 130 yards and his first receiving TD of the season. This week vs. Seattle, the second-year wideout puts on a show and has 100 receiving yards and THREE touchdowns!

Marc Ross: The Arizona Cardinals kept their undefeated record intact last week with a gritty win over the 49ers. This week, however, it's a different story. The Browns' top-ranked ground attack rolls over a Cardinals defense that ranks 29th vs. the run, as Kareem Hunt will eclipse 125 yards rushing. In addition, Odell Beckham scores his first touchdown in over a year.

Full NFL Week 6 schedule

Monday, October 18

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