Staley said that Herbert's prognosis is still to be determined, but a significant injury to his throwing hand with just four games remaining could be season-ending.
The QB will undergo and MRI on Monday to determine how much time he'll miss and if he'll be able to return this year, NFL Network Insider Ian Rapoport reported.
Herbert sustained the injury late in the second quarter while throwing a pass downfield in a crowded pocket. Broncos defensive lineman Zach Allen pulled Herbert to the ground just before letting off the pass, which was incomplete.
Herbert was deemed questionable to return upon exiting the game. He was ruled out as the second half was underway.
Easton Stick came into the game for Herbert on the next Chargers possession, trailing, 7-0, and played the rest of the way as Los Angeles fell to its AFC West rival.
Herbert finished having completed 9 of 17 passes for 96 yards and an interception, while Stick ended the game with 179 yards on 13-of-24 passing.
This is the second time L.A.'s franchise QB has dealt with a hand injury this season.
In Week 4, Herbert suffered a fractured middle finger on his left hand but didn't miss a play in the win over the Raiders. The 25-year-old has yet to miss a game this season, but this new injury is sure to affect his throwing, and it remains to be seen if or for how long it keeps him out moving forward.