Quick change! Colts fumble on the kick return to set up 49ers in prime scoring position

Indianapolis Colts running back Ameer Abdullah fumbles the ball on the kick return for a San Francisco 49ers fumble recovery.

San Francisco 49ers running back Christian McCaffery bolts out of the backfield for a 24-yard gain.

San Francisco 49ers quarterback Brock Purdy completes a 17-yard pass to wide receiver Jauan Jennings.

Indianapolis Colts running back Jonathan Taylor sneaks into the end zone for a 1-yard touchdown.

Indianapolis Colts quarterback Philip Rivers completes a 19-yard pass to tight end Tyler Warren.

San Francisco 49ers kicker Eddy Piñeiro makes a 38-yard field goal.

San Francisco 49ers wide receiver Jauan Jennings leaps to secure 19-yard pass from quarterback Brock Purdy.

Indianapolis Colts kicker Blake Groupe makes a 51-yard field goal.

San Francisco 49ers quarterback Brock Purdy completes a 3-yard touchdown pass to wide receiver Jauan Jennings.

San Francisco 49ers quarterback Brock Purdy rolls out of the pocket to locate tight end George Kittle for a 15-yard gain.

San Francisco 49ers tight end George Kittle catches a 15-yard pass from quarterback Brock Purdy.

San Francisco 49ers kicker Eddy Piñeiro just barely misses a 64-yard field goal attempt that bangs off the crossbar.

Indianapolis Colts kicker Blake Grupe drills a 39-yard field goal.

San Francisco 49ers kicker Eddy Piñeiro makes a 25-yard field goal.

San Francisco 49ers wide receiver Kendrick Bourne secures $500,000 contract bonus after 11-yard gain following a pass from quarterback Brock Purdy.

San Francisco 49ers tight end George Kittle grabs a 17-yard pass from quarterback Brock Purdy.

San Francisco 49ers quarterback Brock Purdy completes a 23-yard pass to wide receiver Skyy Moore.

San Francisco 49ers defensive tackle CJ West bursts through the double team to take down Indianapolis Colts quarterback Philip Rivers for an 8-yard sack.

San Francisco 49ers tight end George Kittle catches an 11-yard touchdown pass from quarterback Brock Purdy.

San Francisco 49ers running back Christian McCaffery rushes for an 18-yard gain.

Indianapolis Colts quarterback Philip Rivers tosses a 17-yard dime to wide receiver Alec Pierce in the back of the end zone for a touchdown.

Indianapolis Colts quarterback Philip Rivers completes a 17-yard pass to wide receiver Alec Pierce.

San Francisco 49ers running back Christian McCaffery catches a 2-yard pass from quarterback Brock Purdy for a touchdown.

San Francisco 49ers quarterback Brock Purdy floats a 22-yard touchdown pass into the hands of wide receiver DeMarcus Robinson.

San Francisco 49ers tight end George Kittle leaps to reel in 26-yard pass from quarterback Brock Purdy.