The Rams will be without their leading rusher for the second week in a row.
Rams coach Sean McVay had told reporters that Henderson would be missing Saturday's practice due to an illness. Henderson was limited all week with the same thigh injury that held him out of Week 13's matchup versus Jacksonville.
Henderson leads the Rams with 648 rushing yards and five rushing touchdowns in 10 games played. The third-year back has also posted career highs in receiving with 27 receptions for 172 yards and three TDs.
Sony Michel will get the bulk of the workload in Henderson's absence for the second straight week. Michel had a season-high 121 rushing yards off 24 carries and found the end zone once in last week's start.