The New England Patriots officially ruled out Jones due to the ankle injury suffered in the Week 3 loss to the Baltimore Ravens.
Brian Hoyer will start Week 4.
NFL Network Insiders Ian Rapoport and Tom Pelissero reported earlier in the week that Jones suffered a "pretty severe" high ankle sprain, per sources informed of the situation.
Patriots coach Bill Belichick remained mum on the severity of Jones' injury this week, calling the QB day-to-day.
"I don't know. He doesn't know. The doctors don't know. Take it as it comes and see what happens," Belichick told reporters Friday of the QB's timeline. "Ultimately, that will be a decision made by the medical people, in consultation with Mac, of course. Like we do with any player. He's no different than any other player. I mean, he is, but I'm just saying the process is the same."
In the end, Jones will miss at least this week and possibly longer, depending on how his rehab tracks in the coming weeks.
Hoyer is set to make his first start since Week 4, 2020, against the Kansas City Chiefs -- a blowout loss in place of Cam Newton. Hoyer hasn't started more than one game in a season since 2017 (0-6 with San Francisco). He has lost his last 11 starts.
The Patriots also ruled out offensive lineman Yodny Cajuste (thumb) and defensive lineman Lawrence Guy (shoulder). Safeties Joshuah Bledsoe (groin), safety Kyle Dugger (knee), defensive lineman Davon Godchaux (back), linebacker Raekwon McMillan (thumb), wide receiver Jakobi Meyers (knee), cornerback Jalen Mills (hamstring) and safety Adrian Phillips (ribs) are questionable to play.