The Carolina Panthers officially listed the star running back as questionable to play in Week 4.
McCaffrey missed Wednesday and Thursday practices due to the thigh issue but returned as a limited participant Friday.
CMC is coming off back-to-back 100-yard rushing games, the first time he surpassed the 100-yard mark in consecutive tilts since doing so in three straight in Weeks 8-10, 2019.
If the running back can't go Sunday, it would cut out the most dynamic part of the Panthers' offense. Chuba Hubbard and D'Onta Foreman would be in line for increased touches if McCaffrey is out Sunday. Panthers coach Matt Rhule could also siphon some of CMC's snaps if he is active against the Cards.