Rank's Flex 150

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NFL Week 6 fantasy flex rankings: Top 150 RB/WR/TE lineup options

Published: Oct 07, 2025 at 02:34 PM Updated: Oct 10, 2025 at 06:41 PM

Adam Rank

NFL.com Writer

Pondering some tough flex choices for your Week 6 fantasy football lineup? Adam Rank sorts through the running backs, receivers and tight ends to present his top 150 flex options, with some useful nuggets of analysis sprinkled in. The ranking is based on a 0.5 PPR scoring format.

NOTE: In a typical week, this ranking will be posted on Tuesday. Injury designations will be added, adjusted or removed as teams' official injury reports are made available. The following three designations will be reflected:

(Q) -- Player is listed as questionable on his team's official injury report.
(D) -- Player is listed as doubtful on his team's official injury report.
(O) -- Player has been ruled out on his team's official injury report.

FLEX RANKINGS: 1-50

Takeaways:

Can anyone tell me why we had guys dropping the ball before reaching the goal line on would-be touchdowns in back-to-back weeks? How is that possible? I would run all the way into the tunnel like Bo Jackson or Forrest Gump if I ever had the chance to score a touchdown in the NFL. You would have thought the infamous DeSean Jackson play from 2008 would have kept people from repeating his mistake. Back in my day (I sound old) I was afraid to eat Pop Rocks and drink a Coke at the same time (ask your parents). How are players not deathly afraid of dropping the ball too soon? I'd carry that thing all the way to hotel with me like that guy who caught that errant Josh Allen pass and ran up the stairs on Sunday night. And in case you're wondering, yes, I did need those six points from Emari Demercado. That was a rough one.
I know we don't talk about quarterbacks much in this space (because it's a flex column, I get it) but my gosh, a huge opportunity awaits Jordan Love this week, with the Bengals' 30th-ranked defense visiting Green Bay coming off the Packers' bye. I like Josh Jacobs to feast, too.
Christian McCaffrey has no rushing touchdowns this season, but the regression to the mean is going to be amazing. CMC does have 52 targets, behind only Puka Nacua and Chris Olave.
Bijan Robinson scored at least 16 fantasy points in each of the first four games of the season. But Robinson was picked early on, if not first overall, in every fantasy draft this year. A guy we picked up off the waiver wire, Rico Dowdle, was fantastic on Sunday, running for 206 yards against the Dolphins. He's the third player in Panthers history to rush for more than 200 yards in a game, joining DeAngelo Williams and Jonathan Stewart (you probably thought I was going to say Christian McCaffrey). Carolina will next face the Cowboys, who are allowing the sixth-most fantasy points per game to running backs this season. Oh yeah, and it's a REVENGE GAME for Dowdle, who will be playing his former team. Just keep an eye on the status of Chuba Hubbard, who did not play in Week 5 due to a calf injury. (EDITOR'S UPDATE: Hubbard was ruled out on Friday's injury report.)
Puka Nacua, the fantasy WR1 this season, has scored at least 22 fantasy points in each of his first five games. He leads the league in targets, receptions and receiving yards this year. Funny, I remember someone on the internet telling me that drafting Nacua in my fantasy league was a bad idea.
Jacory Croskey-Merritt is averaging 6.6 yards per carry this season. He's also rushed for four touchdowns while all other Commanders RBs have combined for one. The Bears are a really favorable draw for them this week. Maybe Chicago's run defense improves with some guys getting healthier coming off a bye. But the non-biased observer in me loves this matchup for Washington's ground game.
I'm curious about Quentin Johnston. He scored a season-low 6.9 fantasy points in Week 5 after he averaged nearly 20 points in his first four games. His fumble set up the Commanders' comeback on Sunday. It all went downhill after that play. I'm having big trust issues with him this week. I'm looking at Ladd McConkey once again. (EDITOR'S UPDATE: Johnston was listed as questionable on Friday's injury report.)
If you're looking for the Chargers running back to roster this week with Omarion Hampton heading to injured reserve, Kimani Vidal is a player I've been high on for a while now. Hassan Haskins went to Michigan, though, so there's a natural bond with head coach Jim Harbaugh. Haskins was the primary backup to Hampton on Sunday. This situation is a little bit messy from a fantasy perspective.
I'm leaving 49ers WRs Ricky Pearsall and Jauan Jennings out this week as they work their way back from injuries, but it's worth monitoring the status of both players leading up to Sunday's game against the Buccaneers. (EDITOR'S UPDATE: On Friday's injury report, Pearsall was ruled out, while Jennings was listed as questionable.)

Tiers: Nos. 1-50 | Nos. 51-100 | Nos. 101-150

FLEX RANKINGS: 51-100

Takeaways:

DeVonta Smith has scored 19-plus fantasy points in two of his last three games. And he's primed for a big performance on Thursday night against the Giants, who have allowed the most receptions to wide receivers this season. That said, I'd want to trade him at this high point if I could. But I can't. Mostly because I don't have any shares of him anywhere. Hypothetically, I would.
Are we seeing the rebirth of Stefon Diggs? I wasn't hyped on Diggs this offseason. I remember telling my colleague Manti Te'o this summer that I wasn't going to be using a lot of draft capital on Diggs. I mean, I did say draft Emeka Egbuka instead. But dang, you're cooking with gas right now if you landed both players.
Darren Waller has 17-plus fantasy points in both games he's played this season. He's scored three receiving touchdowns in the past two weeks. If you didn't pick him up last week, you're probably too late now. If you missed out and still need help at tight end, you're going to need to turn to Mason Taylor or Theo Johnson.
Sorry, this is just a quick aside. How did Patrick Mahomes and Trevor Lawrence lead their teams in rushing on Monday night? I'm sort of heated because I do have tons of Travis Etienne shares and he's been playing really well. The Chiefs are being extremely frustrating with the running back usage. I can live with Kareem Hunt getting all the goal-line work. That's fine. But moving around Isiah Pacheco and the other guy is frustrating. Oh, the other guy is rookie Brashard Smith, who looked fantastic every time he touched the ball against the Jaguars. Is it too much to ask for Matt Nagy to fix this?