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- DT Derrick Brown, the team's 2000 first-round pick, suffered an oblique injury against the Buffalo Bills and did not return. Head coach Matt Rhule said he doesn't believe the injury was serious, and Brown had been cleared to re-enter the game, though they held him out out of an abundance of caution.
- K Zane Gonzalez suffered a groin injury while warming up on the sidelines and was carted off the field in the third quarter. He is questionable to return.
- FB Giovanni Ricci is questionable to return with a groin injury.
- QB Sam Darnold was carted off the field with an ankle injury and did not return to the game.
- RB/WR Ty Montgomery sustained an ankle injury during Friday's game against the Raiders and was ruled out in the second half.
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