Coach Sean McVay said Friday that Stafford is out for Week 13 due to a neck injury.
McVay added that John Wolford would start Sunday's contest against the Seahawks. The 27-year-old backup started Week 10 but suffered a neck injury. He dressed last week, but Bryce Perkins started in the loss in K.C.
Stafford's neck injury, coupled with the Rams' 3-8 record, makes the quarterback's status uncertain for the rest of the season. L.A. could decide to shut down Stafford for the duration of the campaign to ensure he's healthy heading into 2023.
It wouldn't be a surprise to see the Rams use both Wolford and Perkins on Sunday against Seattle.