Struggling to set the perfect fantasy lineup? Let us be your guide. Each week the NFL Fantasy staff will provide you with game-by-game, player-by-player matchup breakdowns in this column to help you set a winning lineup. Think of this as the one-stop shop to crushing your opponent in fantasy football.
Now, onto the best and worst Week 6 fantasy matchups for the remaining games.
New York Jets at Arizona Cardinals: 8:30 p.m. ET on ESPN (Monday)
Ryan Fitzpatrick, QB -- SIT: The Fitzmagic is gone from the Big Apple, and the Amish Rifle simply cannot be trusted in fantasy right now with twice as many interceptions on the season than touchdowns.
Matt Forte & Bilal Powell, RBs -- FLEX: Forte's insane volume from the start of the season has evaporated, leading to more touches for Powell. Forte's the safer start in standard leagues as he'd be the favorite for opportunities near the goal-line, while Powell's ability in the passing game makes him worth a look in deeper PPR formats.
Carson Palmer, QB -- START: Palmer has cleared concussion protocol and is set to face a secondary that continues to be shredded week after week. Get him back into your lineups.
Larry Fitzgerald, WR -- START: Fitzgerald remains the most consistent pass-catcher on this team. He's worth starting every week until further notice.
Michael Floyd, WR -- SIT: Do you like looking at your fantasy roster on Monday morning and getting mad? If so, start Floyd!
Denver Broncos at San Diego Chargers: 8:25 p.m. ET on CBS/NFL Network (Thursday)
Trevor Siemian, QB -- START: The Broncos clearly missed Siemian's presence as rookie Paxton Lynch was simply not ready to start as the reliever in Week 5. Siemian brings value as a low-end streamer going against the Chargers, who have allowed the third-most passing yards in the NFL, but his position as a road quarterback on a short week is dicey.
Virgil Green, TE -- SIT: Green is off the injury report after a multi-week absence. We need to see what kind of usage he gets in his return before considering starting him.
San Francisco 49ers at Buffalo Bills: 1:00 p.m. ET on FOX
Colin Kaepernick, QB -- SIT: The Niners finally made the much-anticipated switch at quarterback. Just because Chip Kelly is starting Kap doesn't mean you have to.
Jeremy Kerley, WR -- FLEX: Kerley has been the only Niners receiver worth owning, though much of his value has come later in games with negative scripts. That might be hard to come by this week.
Torrey Smith, WR -- SIT: Smith might have added value if he and Kap can connect on a few deep throws. But right now, it's not worth the risk to start him.
Vance McDonald, TE -- SIT: We'll see if he suits up this week, but three targets in seven games doesn't sound like the kind of player you want to roll with in your fantasy lineup.
Tyrod Taylor, QB -- SIT: Taylor has been good, not great and there are better quarterbacks with better matchups out there this week.
LeSean McCoy, RB -- START: Why would you sit fantasy's No. 6 running back who's given you 90 yards or a touchdown in every game? You wouldn't. It's that simple.
Robert Woods, WR -- SIT: A number of receivers have far better matchups. There's little reason to take Woods off your bench this week.
Marquise Goodwin, WR -- SIT: He's caught just six of his 21 targets. He can be a home-run hitter, but you'll have to endure a ton of strikeouts.
Philadelphia Eagles at Washington Redskins: 1:00 p.m. ET on FOX
Carson Wentz, QB -- START: Wentz's consistency makes him worth starting consideration against a poor Washington defense if your normal starter has a tough matchup.
Ryan Mathews, RB -- START: Mathews might be in a committee, but he's hard to sit against one of the worst run defenses in the NFL.
Darren Sproles, RB -- FLEX: Mathews might see the bulk of the goal-line carries, but Sproles' overall snap and touch volume make him worth a play -- especially in PPR leagues.
Nelson Agholor, WR -- SIT: The floor is very low and the ceiling isn't high enough to warrant giving Agholor a shot in your lineup.
Matt Jones, RB -- SIT: We could list each of Washington's running backs here and the answer would be the same. Nope.
DeSean Jackson, WR -- FLEX: Jackson has always been a ceiling play because he's not one to rack up a ton of catches. Start him, but know that a low number is a real possibility.
Jamison Crowder, WR -- SIT: A few weeks ago, it looked like Crowder was the guy to own. But with six targets in two games, that fantasy ship may have sailed.
Pierre Garcon, WR -- FLEX: Garçon has picked things up the past two weeks but is still a cautious start against the Philadelphia secondary.
Cleveland Browns at Tennessee Titans: 1:00 p.m. ET on CBS
Marcus Mariota, QB -- START: Mariota was the highest scoring player in fantasy last week thanks to his 60 rushing yards and four total touchdowns. He probably won't repeat 30-plus fantasy points but a matchup against an awful Browns defense makes him a decent streaming candidate for the second straight week.
Derrick Henry, RB -- SIT: Henry is no more than a handcuff to Murray. He should be stashed, but not started.
Baltimore Ravens at New York Giants: 1:00 p.m. ET on CBS
Joe Flacco, QB -- START: Flacco leads the NFL in pass attempts (215) but is tied for the lowest yards per attempt (5.9) with Blaine Gabbert. So it makes sense why Baltimore chose to change up offensive coordinators after last week. Expect Flacco to get back to his gun-slinging ways against the Giants 20th ranked pass defense. He's a 12-team streaming option this week.
Dennis Pitta, TE -- SIT: Pitta had eight catches for just 59 yards last week. His production has been inconsistent but he could see more targets with Smith sidelined. Still, he's a sit until we see that he is more involved.
Breshad Perriman, WR -- FLEX: Perriman will likely take advantage of his best asset, his speed, against a struggling Giants pass defense. Expect Flacco to look his way more frequently as Baltimore is expected to open things up with the deep ball after a major coaching change. Still, he's a boom-or-bust kind of option limiting his appeal to the flex variety.
Eli Manning, QB -- SIT: Manning has struggled of late with just two touchdown passes in his last three games. You can't start him against a solid Baltimore defense on the rise.
Rashad Jennings, RB -- FLEX: Jennings got some limited work in practice ahead of Week 6, and if he starts he's worth considering as a flex option. Just temper expectations against a solid Baltimore run defense.
Odell Beckham Jr., WR -- START: Despite his recent struggles, Beckham is not the kind of fantasy stud you bench in any situation. He finally got into the end zone last week and should see a healthy dose of targets.
Sterling Shepard, WR -- FLEX: Shepard trails Beckham by 18 targets but has just five fewer receptions and one more touchdown than his teammate this season. He's a key role player in this offense and is worth a flex pretty much every week. Just keep in mind that the Giants have been struggling mightily in the passing game recently.
Carolina Panthers at New Orleans Saints: 1:00 p.m. ET on FOX
Jacksonville Jaguars at Chicago Bears: 1:00 p.m. ET on CBS
T.J. Yeldon, RB -- SIT: Yeldon surprisingly got a preponderance of the touches two weeks ago in London. That history doesn't seem likely to repeat itself.
Allen Robinson, WR -- START: A wide receiver with double-digit targets in three of four games is a receiver that's hard to keep on your bench at any time.
Allen Hurns, WR -- SIT: Hurns' 2015 value was mostly predicated on his seven-game touchdown streak. With just one scoring catch this year, Hurns is far less productive.
Julius Thomas, TE -- START: His numbers haven't been great (he was injured) but Thomas is occupying a larger role in the offense than he did a season ago and, now healthy again, should still be productive.
Jordan Howard, RB -- FLEX: The Jags look better against fantasy running backs because opponents are so effective through the air. But Howard should still be able to get over on them.
Alshon Jeffery, WR -- FLEX: At some point, the over-correction is coming for Jeffery, right? Or will we continue to see him frustrated? We like our chances for a decent number this week.
Eddie Royal, WR -- FLEX: Royal has been Hoyer's favorite target in the past several weeks and has become a legit WR3 or flex -- especially in PPR leagues.
Cameron Meredith, WR -- FLEX: After seeing 12 targets last week, it's clear that Hoyer has faith in him. If this turns into a track meet, Meredith should again see plenty of work.
Los Angeles Rams at Detroit Lions: 1:00 p.m. ET on FOX
Case Keenum, QB -- SIT: If you're in a 2QB league, Keenum is usable. However, he's a tough sell otherwise.
Todd Gurley, RB -- FLEX: If Benny Cunningham plays Gurley will lose the passing game volume that inflated his floor the last two weeks ... because Rams. However, this could be the first big game Gurley has on the ground. The Lions give up 5.1 yards per carry but just haven't let up a rushing touchdown.
Marvin Jones, WR -- START: After two simply solid weeks, Jones has a strong shot to hit his ceiling this week. He's still the dominant target monster in this team's passing distribution.
Pittsburgh Steelers at Miami Dolphins: 1:00 p.m. ET on CBS
Antonio Brown, WR -- START: Brown leads the NFL with 37 receptions and is tied for the most receiving touchdowns (five). He's elite and you start him no matter what.
Sammie Coates, WR -- HIGH-END FLEX: Coates broke through last week despite his drop issues. He was seen with a cast on his hand in practice this week due to a finger injury, so his status is worth monitoring, but if he's active he's worth rolling out again as a high-end flex.
Jesse James, TE, -- START:James has three red-zone touchdowns this year, which ties him for the most among tight ends (Zach Miller, Kyle Rudolph). You're sort of banking on the score if you start him, but Big Ben likes to look his way over the middle when Pittsburgh gets close. James should have plenty of opportunities to score against a bad Miami defense.
Ryan Tannehill, QB -- SIT: Tannehill has thrown more interceptions than touchdowns this season and has been sacked 17 times. He'll probably be throwing a lot to keep up with Pittsburgh, but that just means more chances for picks. Bench or drop him.
Arian Foster, RB -- FLEX: There's a chance Foster returns this week after missing time with a groin injury. He's worth flexing since he'd probably get a ton of looks as a pass-catcher as Miami does their best to keep pace with Pittsburgh.
Jarvis Landry, WR -- FLEX: If you play in a PPR format, Landry should be just fine as your WR2. If not, he's no more than a flex play. He's scored just one touchdown in his last 10 games, but has 10-plus targets in four of five contests this season.
Kenny Stills, WR -- SIT: Stills had one target and zero catches last week. His snap count has plummeted the last few weeks and he's no longer fantasy relevant.
Cincinnati Bengals at New England Patriots: 1:00 p.m. ET on CBS
Andy Dalton, QB -- SIT: With New England likely to key in on stopping A.J. Green, Dalton will probably have a tough go in Foxboro. His two touchdown passes last week marked his first multiple-score game all season, but most of his production came in garbage time. You can do better at quarterback this week.
A.J. Green, WR -- START: It's sort of alarming that Green has just two double-digit fantasy outings through five games. Both of which were for 20-plus points, which suggests he's become a boom-or-bust wideout. The Patriots are going to do everything they can to stop him, but you simply can't leave him on the bench.
Giovani Bernard, RB -- FLEX: Bernard took advantage of his starting nod last week with 96 total yards on 14 touches. He could get some extra work in what's likely to be a friendly game script for his style of play. He is well worth flexing against New England.
Tyler Eifert, TE -- SIT: Eifert didn't practice on Wednesday and would have to take some huge steps forward in the coming days in order to suit up. We're not holding our breath, though.
Tom Brady, QB -- START: Brady came back in a big way last week against Cleveland. With so many weapons to help him manufacture fantasy points, he's a weekly QB1, and that includes this week against a Cincy defense that has allowed 11 passing touchdowns in five games.
Rob Gronkowski, TE -- START: Because his teammate, Marty B, put up three touchdowns last week, Gronk had a very quiet 100 yards on five receptions. He looked like his old self, running defenders over in an effort to gain every last yard and logged a season-high 65 snaps. You can start him with confidence on a weekly basis going forward.
Martellus Bennett, TE, -- START: This whole two-tight end thing seems to be working out for New England, and with Brady back it's going to be even more productive. Bennett remains a top-10 option even with Gronk back at it again.
Julian Edelman, WR -- FLEX: Even with Brady back, Edelman didn't have a great game last week and now has fewer than 40 yards in each of his last three contests. He still led the team with 10 targets and is a solid flex option with Brady under center.
LeGarrette Blount, RB -- START: Despite Brady's return, less volume and the fewest rushing yards of the season for the big back, Blount still scored a touchdown against the Browns. For now, he remains an RB2 for fantasy purposes until we see New England really veer away from him. They have no reason to considering his strong play this season, but he may become more touchdown-dependent than he was the first four weeks with Brady out.
Kansas City Chiefs at Oakland Raiders: 4:05 p.m. ET on CBS
Chiefs RBs -- FLEX: This is the most difficult proposition of the week, as no one truly knows how the Chiefs will split up their running back workload between Spencer Ware and Jamaal Charles. If either of the duo are on your roster, they might be worth playing despite the lack of clarity. The Raiders give up 4.89 yards per carry to opposing running backs.
Derek Carr, QB -- START: The Chiefs defensive rankings look strong, but most of that is due to a high interception total. However, six of their eight registered came in one game against Ryan Fitzpatrick. We should not fear this unit, however, as they've allowed a 61.4 completion rate and have just five sacks to their name and were absolutely torched by Ben Roethlisberger before their bye.
Raiders RBs -- SIT: Murray could be back this week and none of his rookie backs did enough to steal the job in relief duty last week. This is a fine matchup, but the lack of clarity is killer.
Atlanta Falcons at Seattle Seahawks: 4:25 p.m. ET on FOX
Russell Wilson, QB -- START: Don't expect Atlanta's defense to repeat their Week 5 performance on the road in Seattle. A rested Wilson should be able to pick apart a secondary allowing 290.2 passing yards and 2.8 passing touchdowns per game.
Tyler Lockett, WR -- FLEX: Lockett's 2016 has been a disappointment, but his ceiling could be worth chasing after having a week for his knee injury to heal up.
Dallas Cowboys at Green Bay Packers: 4:25 p.m. ET on FOX
Ezekiel Elliott, RB -- START: Elliott leads the league in rush attempts (109) and rushing yards (546), but is facing the league's best run defense as the Packers allow just 2.0 yards per carry and 42.8 yards per game. Even in a tough spot, Zeke should see the volume necessary to make him worth a start in fantasy.
Cole Beasley, WR -- SIT: Unless playing in a PPR format, Beasley isn't worth a start on the road against what is looking like a stout Green Bay defense.
Terrance Williams, WR -- FLEX: Only flex Williams if Bryant misses this game. And even then, there are probably better options available.
Aaron Rodgers, QB -- START: Something is still off with Rodgers and this offense, but he should be able to produce against a Dallas defense allowing a 65.2 completion percentage and a nine-to-three TD-to-INT ratio.
Eddie Lacy, RB -- FLEX: Lacy has been solid this year, averaging 5.5 yards per carry, but has yet to find the end zone and suffered a minor ankle injury last week. If he suits up he should be able to produce decent totals against a Dallas front allowing 4.6 yards per carry.
Jordy Nelson, WR -- START: Nelson produced in Week 5, despite an uneven and inefficient performance. He's Rodgers' top target in the red zone and top downfield threat. He's a must-start.
Randall Cobb, WR -- FLEX: It was good to get back on track last week with over 100 receiving yards. He's in another great spot this week, as slot receivers have routinely roasted the Dallas secondary.
Davante Adams, WR -- FLEX: Those in desperate need of a fill-in wide receiver this week could give Adams a shot. He's caught a touchdown in three of four games this year and plays the third-most snaps among Green Bay wideouts.
Indianapolis Colts at Houston Texans: 8:30 p.m. ET on NBC
T.Y. Hilton, WR -- START: Hilton performs better in fantasy at home than on the road, but he's seen double digit targets in every game this season. You can't sit that type of volume.
Brock Osweiler, QB -- SIT: Osweiler has been so bad this year we can't even recommend starting him against one of the most favorable matchups he's seen all season.
Lamar Miller, RB -- START: Expect Miller to bounce back after a terrible week against the vaunted Minnesota defense. Hopefully this is the week Miller's touchdown drought ends ... hopefully.