Jaguars coach Doug Marrone said running back Leonard Fournette (hamstring) and cornerback D.J. Hayden (toe) will not play Sunday.
Fournette's status doesn't come as a big shock. The second-year running back aggravated the injury in Week 4, and Marrone said Monday he didn't know how much time the running back would miss.
Hayden's injury will put more pressure on a Jaguars secondary that has the unenviable task of trying to contain the Patrick Mahomes-led offense.
While Fournette is out for Week 5, the Jaguars have good news with backup running back T.J. Yeldon, who is expected to practice with an ankle injury. The Jaguars, however, don't expect tight end Austin Seferian-Jenkins (core muscle injury), center Brandon Linder (knee, back) and guard Andrew Norwell (knee) to practice.
Here are other injuries we are monitoring:
Hilton leads the Colts with 21 catches for 294 yards on 38 targets, and Thursday will end his streak of 42 consecutive starts.
- Philadelphia Eagles coach Doug Pederson said running back Darren Sproles continues to deal with a hamstring injury and his status is day to day. The team is also monitoring quad injuries affecting running back Corey Clement and offensive tackle Jason Peters.
- Green Bay Packers defensive lineman Muhammad Wilkersonunderwent surgery Tuesday on his fractured ankle that knocked him out for the season, a source told NFL Network Insider Ian Rapoport. Dr. Robert Anderson informed him he'd make a full recovery. Prior to the operation, there was some question about how it would affect his career.
Quarterback Aaron Rodgers (knee), wide receiver Randall Cobb (hamstring) and guardJustin McCray (shoulder) all practiced with the Packers' rehab group. Wide receiver Geronimo Allison remains in concussion protocol, coach Mike McCarthy said.
- New York Giants coach Pat Shurmur said cornerback Eli Apple (groin) and defensive end Olivier Vernon (ankle) are both expected to practice. Shurmur also said wide receiver Sterling Shepard had a cyst removed from his back, should be OK in a "day or two."
- Dallas Cowboys running back Ezekiel Elliott (knee, ankle) fully participated in practice. Wide receiver Cole Beasley (ankle), defensive end DeMarcus Lawrence (shoulder) and defensive tackles Maliek Collins (knee) andAntwaun Woods were all limited.
- The Oakland Raiders placed veteran right tackle Donald Penn on injured reserve because of a groin injury he suffered Sunday, sources told NFL Network Insider Ian Rapoport and NFL Network's MJ Acosta. The move will allow the team to bring him back later this season. Raiders coach Jon Gruden later confirmed the development.
- The Panthers are getting healthy coming out of their bye week. Wide receiver Curtis Samuel (medical illness) and guard Trai Turner (concussion) were both full participants.
Carolina coach Ron Rivera told reporters that tight end Greg Olsen resumed running routes and catching passes as he worked off to the side during practice. Olsen re-fractured his right foot during the season-opener.
- Broncos linebacker Von Miller (thigh) was limited at practice. Linebackers Brandon Marshall (knee) and Shane Ray (wrist) were both full participants.
- Chargers defensive end Joey Bosa (foot), tackle Russell Okung (groin), wideout Travis Benjamin (foot) and defensive tackle Joe Barksdale (knee) all did not participate at practice.