The sprained ankle has clearly limited him and he has been ruled out of Sunday's game against the New York Jets. It marks the first time Mack has missed a regular-season game in his career.
In other Bears injury news, receiver Allen Robinson, who was questionable with a groin injury, also won't play.
Here are other injuries we're monitoring heading into Week 8's Sunday kickoff:
- San Francisco 49ers running back Matt Breida (ankle), originally thought to be sitting out against the Cardinals is expected to play, a source informed Rapoport. "He won't be 100 percent, but he (is) slated to play," Rapoport tweeted before adding that cornerback Richard Sherman (calf) is expected to play.
- Philadelphia Eagles offensive tackle Lane Johnson was carted off with a knee injury during the first quarter of Sunday's game against the Jacksonville Jaguars and will not return. Linebacker Kamu Grugier-Hill suffered a thumb injury. Cornerback Jalen Mills was carted off with a foot injury and did not return to the game.