The 49ers WR is believed to have avoided a major injury and is still being evaluated to learn more about his injury, NFL Network Insider Tom Pelissero reported, per a source.
Head coach Kyle Shanahan told reporters after the game that Samuel did not sustain an ankle fracture. Shanahan said it's most likely a high ankle sprain for Samuel.
With 5:10 remaining in the second quarter, Samuel sustained the injury while getting tackled on a rush up the middle, with his legs twisting under bodies as a Bucs defender corralled him to the ground. Samuel lost a fumble on the play as the ball fell from his grasp once his legs bent back awkwardly.
Samuel immediately grabbed his left leg as he writhed on the turf. With his teammates on bended knee as he was attended to by San Francisco's staff, Samuel was carted to the locker room.
San Francisco held a 21-0 lead over the Bucs at the time of Samuel's exit. The 49ers' All-Pro WR scored the game's first touchdown on a 13-yard run and had four receptions for 43 yards before leaving the game.
Samuel has emerged as one of the more unique offensive weapons in the NFL with his ability to line up all over the field and his uncanny proficiency at making splash plays after a catch or run. In 11 games played this season, Samuel has 54 receptions for 612 yards and two TDs while adding 228 rushing yards and three more scores.
With the 49ers playing against the Seahawks on Thursday, Samuel's status will be monitored closely heading into the NFC West game.